The CSS3 way (no extra markup)
Target the first character of the first paragraph using pseudo class selectors. No extra markup needed, but no IE < 9 support.
<p> Just a normal sentence. </p>
p:first-child:first-letter { color: #903; float: left; font-family: Georgia; font-size: 75px; line-height: 60px; padding-top: 4px; padding-right: 8px; padding-left: 3px; }
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